It may take up to three years to show bacteria, viruses or cell cultures into a vaccine. Since vaccines are injected straight into your body, safety and purity have the highest priority in production. Snotty on the plant equipment are correspondingly high, for instance, in the tabs on pressure. The PG43SA series of diaphragm pressure gauges from WIKA are tailored to the.
Designed completely in hygienic design: the diaphragm pressure gauges of the PG43SA series
Three instrument models from which to choose
The hygienic instruments with flush, welded diaphragm elements are suitable for pressure monitoring in all regions of vaccine production. This applies, not merely to the ?upstream? and ?downstream? stations, but additionally to the support processes.
There are three 3A and EHEDG-certified models to pick from:
PG43SA-S
PG43SA-D with integrated diaphragm element monitoring
PG43SA-C particularly compact with back mount process connection
Which variant a user chooses, and of which point along the way, depends upon their safety requirements and the installation conditions ? even though model PG43SA-S already meets a large section of the requirements for pressure monitoring.
Critical situation instantly
The further the vaccine production progresses, the more valuable the product becomes. During the ?downstream? filtration processes, the future active component is increasingly purified. Here, pressure monitoring supplies the decisive information as to whether the filters remain working correctly or are clogging up and ought to be replaced. The model PG43SA-S with red limit value marking, for instance, enables a critical situation to be detected, unmistakably, at a glance.
In filtration plant, pressure monitoring can be used, among other things, to check on the filter status and to draw focus on any clogging of the filter in good time.
Problem-free installation
That the compact nature of the instruments may also be important in this is illustrated by a filtration system at a vaccine manufacturer in China: in cases like this, a peristaltic pump conveys the active ingredient to the capsule filter with a hose. The challenge of the extremely cramped available space meant a little measuring instrument was required, and the model PG43SA-C met this.
The instrument could be easily attached to the hose before and after the filter due to its process connection being built-into the case ? a patented design. This measuring solution shows the operator if the pump and filter are working normally. The PC43SA-C supplies a good plan view because of this. It is therefore also suitable for pressure monitoring in vertical pipelines.
The models in the PG43SA series, like all diaphragm pressure gauges, as a result of their mechanical principle, always reliably indicate the procedure pressure. They measure with high overload safety and independently of electrical energy. This meets the safety requirements, particularly when transporting the intermediate products and the finished vaccine. They are transported in mobile tanks from the bioreactor via chromatograph and filtration through to filling into ampoules.
Vaccine transport in mobile tanks is known as a particularly sensitive process step. The hygienic diaphragm pressure gauges of the PG43SA series provide all of the necessary pressure information anytime, independent of electrical power.
Multiple tasks in a single application
When monitoring the pressure at the tanks, the PG43SA instruments fulfil several tasks: During transport, it is important to check if the pressure remains constant. This is also a leak test: a falling pressure may be because of leaking valve or perhaps a damaged seal. After emptying the tank at the transfer point, one look at the display can determine whether there is still pressure in the tank or whether it can be opened without danger. The same pertains to pressure monitoring during tank cleaning and the pressure test before refilling.
In tank applications, in addition to the measurement quality described, another advantage of diaphragm pressure gauges comes to the fore: the instruments work with a ?dry? measuring cell. This eliminates the risk of product contamination by a system fill fluid, as may be the case with conventional diaphragm seal systems. In this manner, they prevent potential damage that could amount to millions.
Further risk minimisation
In these and similar sensitive processes, the model PG43SA-D really helps to further minimise risks to the vaccine. The instrument has an integrated diaphragm element monitor with red/white indicator. In the unlikely event that the very robust measuring element should break due to extreme process conditions or rough mechanical influences, the patented monitoring function immediately reports the damage via a ?red? indicator. Another barrier in the instrument maintains the separation of process and environment.
Suitable for CIP/SIP and autoclavable
Process reliability in vaccine production includes residue-free cleaning of the gear after each batch. Because of their hygienic design, the PG43SA diaphragm pressure gauges are ideal for CIP/SIP cleaning processes and are all autoclavable.
Note
You can find an overview and technical information on the PG43SA series hygienic diaphragm pressure gauges on the WIKA website or in our flyer: ?Safe and reliable: Pressure displays in hygienic design?. You would like to buy hygienic diaphragm pressure gauges? In our WIKA online-shop you will discover some of our standard designs. If you have any questions, your contact will gladly assist you to.
Also read our articles
Pressure gauges for pharmaceutical processes: Flush-mounted dry measurement
Hygienic pressure gauge: IP68 with cleaning from the outside
The following video also informs you concerning the PG43SA instruments: